A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/727 (2006.01) A61K 31/00 (2006.01) A61K 31/737 (2006.01) A61P 7/02 (2006.01) A61P 43/00 (2006.01) C08B 37/00 (2006.01) C08B 37/10 (2006.01)
Patent
CA 2458852
The present invention relates to compositions and methods for the treatment of diseases or conditions characterised by excess thrombin generation or activity. In particular, the invention provides conbination compositions comprising low molecular weight heparin (LMWH) and low molecular weight dermatan sulphate (LMWDS). Such compositions are well suited for the treatment of said diseases or conditions, and they exert an effect which is greater than sum of the effects of LMWH and LMWDS if dosed as single agents, i.e. the combination conposition exerts a synergistic effect.
La présente invention se rapporte à des compositions et à des procédés destinés au traitement de maladies ou d'états pathologiques caractérisés par une production ou une activité excessive de thrombine. L'invention se rapporte en particulier à des compositions de combinaison comportant de l'héparine de faible poids moléculaire (LMWH) et du dermatane sulfate de faible poids moléculaire (LMWDS). Ces compositions conviennent particulièrement aux traitements des maladies et états pathologiques précités car elles exercent un effet qui est supérieur à la somme des effets de LMWH et LMWDS administrés séparément, c'est-à-dire que la composition de combinaison exerce un effet synergétique.
Betton Johansen Kristian
Hirsh Jack
Petersen Christian Frimundt
Weitz Jeffrey I.
Borden Ladner Gervais Llp
Glycodesign Holdings Ltd.
Leo Pharma A/s
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