Antithrombotic compound

C - Chemistry – Metallurgy – 07 – H

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C07H 15/26 (2006.01) A61K 47/48 (2006.01) A61P 7/02 (2006.01) C07H 15/00 (2006.01) C07H 15/08 (2006.01)

Patent

CA 2624867

The present invention relates compounds of the formula I : oligosaccharide- spacer-GpIIb/IIIa antagonist I, wherein the oligosaccharide is a negatively charged pentasaccharide residue of the structure (I), the charge being compensated by positively charged counterions; the spacer is an essentially pharmacologically inactive linking residue of a length of 15-50 atoms; the GpIIb/IIIa antagonist is a residue derived from tirofiban or an analogue thereof; or a pharmaceutically acceptable salt thereof or a prodrug or a solvate thereof. The compounds of the invention have antithrombotic activity and can be used in treating or preventing thrombotic diseases.

L'invention concerne des composés de formule (I) : oligosaccharide-espaceur- antagoniste de GpIIb/IIIa, dans laquelle l'oligosaccharide est un résidu de pentasaccharide à charge négative de structure (I), la charge étant compensée par des contre-ions à charge positive ; l'espaceur est un résidu de liaison sensiblement inactif sur le plan pharmacologique d'une longueur comprise entre 15 et 50 atomes ; l'antagoniste de GpIIb/IIIa est un résidu dérivé de tirofiban ou d'un analogue de celui-ci ; ou un sel acceptable sur le plan pharmaceutique de ceux-ci ou un promédicament ou un solvate de ceux-ci. Les composés de l'invention présentent une activité antithrombotique et peuvent être utilisés dans le traitement ou la prévention de maladies thrombotiques.

LandOfFree

Say what you really think

Search LandOfFree.com for Canadian inventors and patents. Rate them and share your experience with other people.

Rating

Antithrombotic compound does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antithrombotic compound, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antithrombotic compound will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFCA-PAI-O-1660195

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.