Antithrombotic compound

Details Antithrombotic compound Antithrombotic compound

C - Chemistry, Metallurgy

07

H

C07H 15/26 (2006.01) A61K 31/70 (2006.01) A61K 31/7028 (2006.01) A61K 38/14 (2006.01) A61P 7/02 (2006.01) C07H 3/06 (2006.01) C07K 9/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2393042

The present invention relates to compounds of the formula (I), wherein R is independently SO3- or CH3; the spacer is a flexible spacer of a length of 13- 25 atoms; the charge of the pentasaccharide residue is compensated by positively charged counterions; and the total number of sulfate groups in the pentasaccharide residue is 4, 5 or 6; or a pharmaceutically acceptable salt, a prodrug or a solvate thereof. The compounds of the invention have antithrombotic activity and can be used in treating or preventing thrombin- related diseases.

L'invention concerne des composés représentés par la formule (I), dans laquelle R représente indépendamment SO¿3??-¿ ou CH¿3?, l'espaceur est un espaceur flexible d'une longueur de 13-25 atomes, la charge du résidu pentasaccharide est compensée par des contre-ions chargés positivement, et le nombre total de groupes sulfate dans le résidu pentasaccharide est de 4, 5 ou 6 ; ou un sel, un précurseur ou un solvate pharmaceutiquement acceptables de ces composés. Ces composés présentent une activité antithrombotique et peuvent être utilisés pour le traitement ou la prévention des pathologies associées à la thrombine.

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