A - Human Necessities – 01 – N
Patent
A - Human Necessities
01
N
A01N 33/02 (2006.01) C07C 215/00 (2006.01) C07C 255/00 (2006.01) C07D 317/22 (2006.01)
Patent
CA 2408220
A new inhibitor of microtubule assembly (IC50 0.59 µM); with antineoplastic properties, denominated "dioxostatin", has been synthesized and its effectiveness against human cancer and murine P388 lymphocytic leukemia cell lines demonstrated. Dioxostatin hs the following structure (I).
L'invention concerne un inhibiteur d'ensemble microtubule (IC¿50? 0,59 µM) présentant des propriétés antinéoplasiques, appelé "dioxostatine", que l'on a synthétisé et dont l'efficacité contre le cancer chez l'être humain et la leucémie lymphocytaire P388 murine a été démontrée. La dioxostatine a la structure (I) ci-après.
Lippert John W. III
Pettit George R.
Acti Ng For And On Behalf Of Arizona State University Arizona Board Of Regents A. Body Corporate Of The State Of Arizo
Borden Ladner Gervais Llp
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