Antitumor agent

A - Human Necessities – 61 – K

Patent

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Details

A61K 33/24 (2006.01) A61K 31/167 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2326761

An antitumor agent comprising a stilbene derivative and a platinum coordination compound as the active ingredients is provided. By employing these two types of active ingredients in combination, the antitumor activity is improved by a synergistic effect, so that it may be expected to be used as an antitumor agent excellent in safety. In particular, when the stilbene derivative exhibiting an antitumor activity is used in combination with the above platinum coordination compound, the antitumor activity inherent to the stilbene derivative is further enhanced to give an antitumor agent having an improved efficaciousness which is particularly adequate for treating malignant tumors. Further, there are also provided uses of these active ingredients as the pharmaceutical preparation and for the treatment thereof and the like, as well as methods for using them therefor.

L'invention concerne des agents antitumoraux contenant des dérivés de stilbène et des composés de coordination platine comme ingrédients actifs. Du fait de l'utilisation combinée de ces deux types d'ingrédients actifs, ces agents sont considérés comme des agents antitumoraux très sûrs, présentant une activité antitumorale synergétiquement améliorée. Lorsqu'on utilise les composés de coordination platine associés aux dérivés stilbène, l'activité antitumorale inhérente à ces dérivés est accrue, ce qui produit des agents antitumoraux améliorés possédant une efficacité accrue particulièrement indiquée pour traiter des tumeurs malignes. L'invention concerne, en outre, l'utilisation de ces ingrédients actifs comme médicaments ou comme thérapie, etc. ainsi que les procédés correspondants.

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