Antitumor agents comprising a targeting portion and an...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61K 47/42 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2518237

The present invention provides an antitumor agent comprising a targeting portion and an immune response triggering portion. The targeting portion may be an antibody fragment or a tumor vasculature binding peptide. The immune response triggering portion may be an Fc fragment of immunoglobulin G (IgG), a fragment of the Fc fragment of IgG that exhibits the same biological function as the Fc region, or the extracellular domain of foreign major histocompatability complex (MHC). The antitumor agent is useful for inhibiting tumor growth, inhibiting tumor angiogenesis and treating diseases associated with neovascularization.

La présente invention concerne un agent antitumoral comprenant une partie de ciblage et une partie de déclenchement de réponse immunitaire. La partie de ciblage peut être un fragment d'anticorps ou un peptide de liaison de système vasculaire tumoral. La partie de déclenchement de réponse immunitaire peut être un fragment Fc d'immunoglobuline G (IgG), un fragment du fragment Fc d'IgG qui présente la même fonction biologique que la région Fc ou le domaine extracellulaire d'un complexe majeur d'histocompatibilité (CMH) étranger. L'agent antitumoral selon cette invention est utilisé pour inhiber une croissance tumorale, inhiber une angiogenèse tumorale et traiter des maladies associées à une néovascularisation.

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