Antitumor and immunosuppressive 4-carbamoyl...

Details Antitumor and immunosuppressive 4-carbamoyl... Antitumor and immunosuppressive 4-carbamoyl...

C - Chemistry, Metallurgy

07

D

260/305, 260/314

C07D 233/90 (2006.01)

Patent

CA 1166259

Abstract of the Disclosure There are provided compounds of the formula: Image wherein R is a mono-substituted benzoyl group which is substituted with a phenyl group, an alkanoyl group, a formyl group, a halogeno-alkyl group, an aralkyloxy group, a phenoxy group, an alkoxycarbonyl group, an aral- kyloxycarbonyl group, an alkanoyloxy group, a benzoyl group, a carboxyl group, a hydroxy group, a group of the formula: Image (wherein X1 and X2 are a hydrogen atom or u lower alkyl group), an aralkyloxycarbonylamino group, a lower alkoxy- carbonylamino group, a carboxyamino group or a carbamoyl group; a cinnamoyl group which may be substituted at a position or the phenyl ring with an alkyl group, an alkoxy group, an aryl group, a nitro group, a methylene- dioxy group, a formyl group, a halogeno-alkyl group, a halogen atom, a hydroxy group, a carboxyl group, an amino group or a cyano group; or a benzoyl group substi- tuted with from two to five of the same or different substituents selected from the group consisting of alkyl groups, alkoxy groups, aralkyloxy groups, nitro group, halogen atoms, hydroxy group, alkanoyloxy groups, formyl group, carboxy group, alkylthio groups, alkylsulfonyl groups, groups of the formula: Image (wherein X1 and X2 are a hydrogen atom or a lower alkyl group), sulfo group and sulfamoyl group; or its non-toxic salt, and a process for producing them. The compounds are useful as antitumor agents and immunosuppressants.

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