Antitumor antibacterial agents

Details Antitumor antibacterial agents Antitumor antibacterial agents

C - Chemistry, Metallurgy

12

P

195/89, 530/15.1

C12P 13/04 (2006.01) C07K 7/06 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1165709

ABSTRACT An antitumor antibacterial complex referred to as BBM-928 is described which is produced by microbiological fermentation under controlled conditions using a species of actinomycetes. The bioactive components of the complex have pronounced antitumor activity and are moderately to weakly active against gram-positive and acid fast bacteria but practically inactive against gram-negative bacteria and fungi. Based on median survival time, the component designated BBM-928A is substantially more active than mitomycin C by a factor of 10 to 300 fold against intraperitoneally implanted mouse tumors.

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