Antitumor antibiotic bu-3983t

Details Antitumor antibiotic bu-3983t Antitumor antibiotic bu-3983t

C - Chemistry, Metallurgy

12

P

167/100, 530/11,

C12P 21/00 (2006.01) A61K 45/08 (2006.01) C07G 11/00 (2006.01) C12N 1/20 (2006.01) C12P 1/06 (2006.01)

Patent

CA 2027601

ABSTRACT OF THE DISCLOSURE The present invention relates to a novel antitumor antibiotic, BU3983T, and a process for preparing same by culturing microorganisms belonging to the genus Actinomadura. This compound demonstrates a high level of antitumor activity against mouse B16 melanoma. An Actinomadura, Strain No. Q886-2, was isolated from a soil sample collected in Batangas, Luzon Island, Philippines. The new antitumor antibiotic BU-3983T was obtained by fermentation of this strain. Based upon the morphology, cultural and physiological characteristics and cell chemistry, the above-mentioned strain was identified as a species of Actinomadura, i.e., Actinomadura verrucosospora.

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