Antitumor antibiotics ma 144-m .sub.1 and ma 144- m.sub.2

Details Antitumor antibiotics ma 144-m .sub.1 and ma 144- m.sub.2 Antitumor antibiotics ma 144-m .sub.1 and ma 144- m.sub.2

C - Chemistry, Metallurgy

07

H

195/101

C07H 17/08 (2006.01) C07H 15/252 (2006.01) C12P 19/56 (2006.01)

Patent

CA 1097238

ABSTRACT OF THE DISCLOSURE New antitumor agents designated MA 144-M1 and MA 144-M2, which are anthracycline glycosides and inhibit the growth of gram-positive bacteria, e.g. Staphyococcus aureus, Bacillus subtilis and Sarcina lutea, and inhibit the growth of animal tumors such as leukemia L 1210, P 388 and sarcoma 180 are produced by fermentation of MA 144- producing strains of streptomyces and by the chemical or enzymatic conversion of aclacinomycin A or cinerubin A.

275564

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