A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/40 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) C07C 233/07 (2006.01) C07D 211/14 (2006.01) C07D 295/13 (2006.01) C07D 295/185 (2006.01) C07D 295/24 (2006.01) C07D 401/12 (2006.01)
Patent
CA 2346873
Chrysene derivatives having formula (I) have been found to have antitumor activity. In this formula, at least one of R1-R12 is -R13Z, where R13 is a substituted or unsubstituted amino or amido group having from 1-12 carbon atoms, and Z is a substituted or unsubstituted heterocyclic group having from 1-12 carbon atoms; and the remainder of R1-R12 are independently selected from the group consisting of hydrogen, substituted or unsubstituted amino or amido groups having 1-12 carbon atoms, nitro, and substituted or unsubstituted hydrocarbyl groups having from 1-12 carbon atoms.
Dérivés de chrysène de formule (I) qui possèdent une activité antitumorale. Dans ladite formule, au moins un parmi les éléments R¿1?-R¿12? représente -R¿13?Z, R¿13? étant un groupe amino ou amido substitué ou non substitué ayant 1 à 12 atomes de carbone et Z étant un groupe hétérocyclique substitué ou non substitué ayant 1 à 12 atomes de carbone. Les éléments de R¿1? à R¿12? restants sont indépendamment sélectionnés dans le groupe constitué par hydrogène, des groupes amino ou amido substitués ou non substitués ayant 1 à 12 atomes de carbone, nitro et des groupes hydrocarbyle substitués ou non substitués ayant 1 à 12 atomes de carbone.
Banik Bimal K.
Becker Frederick F.
Bereskin & Parr
Board Of Regents The University Of Texas System
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