Antitumor composition containing a synergistic combination...

Details Antitumor composition containing a synergistic combination... Antitumor composition containing a synergistic combination...

A - Human Necessities

61

K

A61K 31/70 (2006.01) A61K 31/47 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2324610

There are provided the combined use of 4-demethoxy-3'-deamino-3'-aziridinyl-4'- methansulfonyl daunorubicin or 4-demethoxy-N,N-bis(2-chloroethyl)-4'- methansulfonyl daunorubicin and an antineoplastic topoisomerase I inhibitor in the treatment of tumors and the use of 4-demethoxy-3'-deamino-3'-aziridinyl-4'- methansulfonyl daunorubicin in the treatment of brain tumors.

L'invention concerne l'utilisation combinée de 4-déméthoxy-3'-désamino-3'-azidirinyl-4'-méthansulfonyle daunorubicine ou de 4-déméthoxy-N,N-bis(2-chloroéthyl)-4'-méthansulfonyle daunorubicine et un inhibiteur antinéoplasique de la topoisomérase I, dans le traitement de tumeurs. Elle porte aussi sur l'utilisation de 4-déméthoxy-3'-désamino-3'-aziridinyl-4'-méthansulfonyle daunorubicine dans le traitement de tumeurs du cerveau.

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