Antitumor compound and therapeutic uses thereof

Details Antitumor compound and therapeutic uses thereof Antitumor compound and therapeutic uses thereof

A - Human Necessities

61

K

A61K 31/403 (2006.01) A61P 9/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2493202

The use of an arylidene 2-indolinone derivative for treating tumors involving Met, PDGF-R, FGF-RI, FGF-R3 and Kit tyrosine kinases, or the oncoproteins of Ret family is disclosed. The invention also provides pharmaceutical compositions comprising laid arylidene 2-indolinone derivative as well as a kit comprising, in separate containers, said derivative and an anti-cancer or anti-tumor agent.

L'invention concerne l'utilisation d'un dérivé arylidène 2-indolinone pour le traitement de tumeurs impliquant des Met, des PDGF-R, des FGF-RI, des FGF-R3 et des Kit tyrosine kinases, ou les oncoprotéines de la famille Ret. L'invention concerne également des compositions pharmaceutiques comprenant ledit dérivé arylidène 2-indolinone, ainsi qu'une trousse comprenant, dans des contenants séparés, ledit dérivé et un agent anticancéreux ou antitumoral.

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