A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/132 (2006.01) A61K 31/44 (2006.01) A61K 31/506 (2006.01) A61K 31/53 (2006.01) A61K 33/24 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2569739
The present invention provides an antitumor effect potentiator, a method for treating cancer using a plurality of pharmaceutical preparations having excellent antitumor activity, and an antitumor preparation. In particular, the present invention provides an antitumor effect potentiator for potentiating the antitumor activity of an antitumor preparation comprising tegafur in a therapeutically effective amount, gimeracil in an amount effective for potentiating an antitumor effect, and oteracil potassium in an amount effective for inhibiting a side effect, the antitumor effect potentiator comprising cis-oxalate(1R,2R-diaminocyclohexane)platinum(II) in an amount effective for potentiating the antitumor effect; a method for treating cancer comprising the step of concomitantly administering tegafur in a therapeutically effective amount, gimeracil in an amount effective for potentiating an antitumor effect, oteracil potassium in an amount effective for inhibiting a side effect, and cis-oxalate(1R,2R- diaminocyclohexane)platinum(II) in an amount effective for potentiating the antitumor effect; an antitumor preparation in a pharmaceutical form comprising a plurality of pharmaceutical agents each of which contains one of the active ingredients consisting of tegafur, gimeracil, oteracil potassium, and cis- oxalate(1R,2R-diaminocyclohexane)platinum(II), or each of which contains such active ingredients in any combination, or in a pharmaceutical form comprising a single pharmaceutical agent containing all the active ingredients; and a kit.
Agent renforçant un effet antitumoral comprenant comme ingrédient actif une quantité efficace de cis-oxalato(1R,2R-diaminocyclohexane)platine (II) de façon à accroître l'activité antitumorale d'un agent antitumoral contenant une quantité efficace du point de vue thérapeutique de tégafur, une quantité, efficace pour l'accroissement de l'effet antitumoral, de giméracil et une quantité, efficace pour la suppression des effets secondaires, d'otéracil potassium ; et agent antitumoral correspondant. De plus, il est fourni un procédé de thérapie pour le cancer, caractérisé en ce qu'on administre de façon concomitante à un mammifère une quantité, efficace pour l'accroissement de l'effet antitumoral, de cis-oxalato(1R,2R-diaminocyclohexane)platine (II). Encore en plus, il est fourni un agent antitumoral constitué d'une forme de préparation pharmaceutique composée d'au moins deux préparations séparées contenant des ingrédients efficaces comprenant du tégafur, du giméracil, de l'otéracil potassium et du cis-oxalato(1R,2R-diaminocyclohexane)platine (II) chacun seuls ou en association arbitraire des uns avec les autres ou bien d'une forme de préparation pharmaceutique comprenant une unique préparation contenant tous les ingrédients efficaces. Encore en plus, il est fourni un kit correspondant.
Koizumi Katsuhisa
Nukatsuka Mamoru
Takechi Teiji
Uchida Junji
Marks & Clerk
Taiho Pharmaceutical Co. Ltd.
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