Antitumor indolopyrrolocarbazole derivatives

Details Antitumor indolopyrrolocarbazole derivatives Antitumor indolopyrrolocarbazole derivatives

C - Chemistry, Metallurgy

07

H

C07H 19/23 (2006.01) A61K 31/70 (2006.01) C07C 243/14 (2006.01) C07C 243/16 (2006.01) C07D 403/04 (2006.01) C07D 403/14 (2006.01) C07D 487/14 (2006.01) C07F 7/10 (2006.01) C07H 19/044 (2006.01) C07H 23/00 (2006.01)

Patent

CA 2190007

This invention relates to compounds of the general formula (see formula I) or pharmaceutically salts thereof, wherein R1 and R2 each represent an OH group, R1 is located at the 1- or 2-position, R2 is located at the 10- or 11-position, R2 is located at the 11-position when R1 is located at the 1-position, and R2 is located at the 10-position when R1 is located at the 2-position. The compounds of the present invention have an excellent antitumor effect and are hence useful as antitumor agents in the field of medicine.

Composé représenté par la formule générale (I), ou sel pharmaceutiquement acceptable de celui-ci. Dans la formule, R<1> et R<2> représentent chacun OH, R<1> étant présent dans la position 1 ou 2 tandis que R<2> est présent dans la position 10 ou 11, à la condition que lorsque R<1> se trouve dans la position 1, R<2> soit dans la position 11 et, quand R<1> se trouve dans la position 2, R<2> soit dans la position 10. Du fait de son excellent effet antitumoral, ce composé est utile en tant que médicament antitumoral dans le domaine médical.

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