Antitumor protein hybrid and process for the preparation...

Details Antitumor protein hybrid and process for the preparation... Antitumor protein hybrid and process for the preparation...

A - Human Necessities

61

K

167/129, 530/15.

A61K 39/395 (2006.01) A61K 47/48 (2006.01)

Patent

CA 1163198

ABSTRACT OF THE DISCLOSURE Antitumor protein hybrid, composed of a moiety which is substantially the fragment Fab of an antitumor immunogloblin and a moiety which is the sub- unit A of ricin, which is expressed by the following formula (I): Fab?S1-(X)n-S2-RA)m ..................(I) (where Fab indicates a moiety which is substantially the fragment Fab of an antitumor immunogloblin; RA indicates a moiety which is the subunit A of ricin; X indicates a divalent organic radical; S1 and S2 are both sulfur atoms, S1 indicating a sulfur atom arising from the disulfide bond (-S-S- bond) in an immunoglobulin and S2 a sulfur atom arising from the disulfide bond in ricin; n stands for 0 or 1 and m stands for an integer of 1 to 5). This antitumor protein hybrid has remarkable and specific cytotoxicity against tumor cells.

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