Antitumor vaccines

Details Antitumor vaccines Antitumor vaccines

A - Human Necessities

61

K

A61K 39/00 (2006.01) A61K 9/127 (2006.01) A61K 39/39 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 16/42 (2006.01)

Patent

CA 2123696

Tumor-associated antigens which caracterize tumors of given histologic types are exemplified by CO-029, which is asso- ciated with tumors of the gastrointestinal tract, colorectum and pancreas, and by GA-733-2, which is associated with tumors of the gastrointestinal tract, prostate, cervix, ovary, bladder, lung, breast, colorectum and pancreas. These antigens, which are broad- ly shared by these tumors, can be synthetically prepared, independent of the tumor itself. These independently prepared antigens are useful as active ingredients in compositions which provide therapeutic protocols to subjects that harbor such tumors or are at risk from such tumors. The vaccine compositions of the invention have enhanced antigenicity by virtue of encapsulation of these antigens in liposomes or covalent coupling of the antigens with liposomes.

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