Antitumoral 18a-homoestra-1,3,5(10)-trien-3-yl 2-substituted...

C - Chemistry – Metallurgy – 07 – J

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C07J 41/00 (2006.01) A61K 31/565 (2006.01) C07J 31/00 (2006.01)

Patent

CA 2516185

The invention relates to the use of compounds of a general formula (I), wherein R2, R14 to R17 and X groups have the following significance: R2 is C1- C5-Alkyl, C1-C5-Alkoxy or a -O-C<SB>N</SB>FmHo rest, wherein n=1,2,3,4,5 or 6, m>1 and m+o=2n+1, R14 and R15 separately designate hydrogen or together a methyl group or a supplementary liaison, R16 is hydrogen; R17 is hydrogen, hydroxy, C1-C5-Alkyl, C1-C5-Alkoxy or SO3NHX; X is hydrogen, C1-C5-alkyl or C1- C5 acyl. In the cycle B and D of a steroid skeleton, stippled lines can additionally represent up to two double bonds. The salts of said compounds which are pharmaceutically acceptable for preparing a drug are also disclosed.

L'invention concerne l'utilisation de composés de formule générale (I), dans laquelle les groupes R?2¿, R?14¿ à R?17¿ et X ont les significations suivantes: R?2¿ représente alkyle C¿1?-C¿5?, alcoxy C¿1?-C¿5? ou un reste -O-C¿n?F¿m?H¿o?, dans la mesure où n=1,2,3,4,5 ou 6, m>1 et m+o=2n+1 ; R?14¿ et R?15¿ signifient chacun hydrogène ou bien ensemble un groupe méthyle ou une liaison supplémentaire ; R?16¿ désigne hydrogène ; R?17¿ signifie hydrogène, hydroxy, alkyle C¿1?-C¿5?, alcoxy C¿1?-C¿5? ou SO¿3?NHX, X désigne hydrogène, alkyle C¿1?-C¿5? ou acyle C¿1?-C¿5?. Dans le cycle B et D du squelette stéroïdique, les lignes en pointillés peuvent représenter en outre jusqu'à deux liaisons doubles. La présente invention porte également sur les sels de ces composés pharmaceutiquement acceptables pour la préparation d'un médicament.

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