A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01)
Patent
CA 2616957
The present invention describes a new group of bioconjugates which can be obtained by means of indirect synthesis, via a molecular spacer, between hyaluronic acid and/or its derivatives and drugs with an antitumoral activity belonging to different groups, their preparation process and use in the oncological field. The new derivatives, in relation to the type of bond and Substitution degree, have different physico-chemical properties which improve their tolerability and efficiency and allow a more accurate modulation of the dosage, exploiting an active targeting mechanism.
L'invention concerne un nouveau groupe de bioconjugués pouvant être obtenus par synthèse indirecte, via un espaceur moléculaire, entre un acide hyaluronique et/ou ses dérivés et des médicaments à activité antitumorale appartenant à différents groupes; leur procédé de préparation; et leur utilisation dans le domaine oncologique. Ces nouveaux dérivés, en fonction du type de liaison et du degré de substitution, possèdent différentes propriétés physico-chimiques qui permettent d'améliorer leur tolérabilité et leur efficacité et favorisent une modulation du dosage plus précise exploitant un mécanisme de ciblage actif.
Bettella Fabio
Renier Davide
Fidia Farmaceutici S.p.a.
Robic
LandOfFree
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