C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 515/22 (2006.01) A61K 35/00 (2006.01) A61K 35/56 (2006.01) C07D 221/00 (2006.01) C07D 241/00 (2006.01) C07D 291/00 (2006.01) C07D 317/00 (2006.01)
Patent
CA 2406080
Compounds having a fused ecteinascidin five ring system with a 1,4 bridge having the structure of formula (VIa or VIb) and compounds in which the -NH2 or -OH of the 1,4 bridge is derivatised are disclosed. Such compounds are useful in the treatment of tumours.
L'invention se rapporte à des composés possédant un système condensé à cinq anneaux d'ecteinascidines comportant un pont 1,4 ayant la structure représentée par la formule (VIa ou VIb) et à des composés dans lesquels le groupement NH¿2? ou OH du pont 1,4 est issu d'une dérivation. Ces composés s'avèrent utiles dans les traitements antitumoraux.
Chicharro Jose Luis
Fernandez Carolina
Flores Maria
Francesch Andres
Gallego Pilar
Marks & Clerk
Pharma Mar S.a.
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