Antitumour 1,5-diazaanthraquinones

C - Chemistry – Metallurgy – 07 – D

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C07D 471/04 (2006.01) A61K 31/44 (2006.01) C07D 221/00 (2006.01)

Patent

CA 2345917

Compounds having formula (I) wherein R3, R4, R7, and R8 are independently selected from the group consisting of hydrogen, lower alkyl, halogen, amine, mono(lower)alkylamine, di(lower)alkylamine, phenyl, or substituted phenyl possess antitumour activity and are new with the exception of the compound in which R3, R4, R7, R8 are all hydrogen and the compound in which R3 and R7 are hydrogen, R4 is chlorine, and R8 is a 2-nitrophenyl group.

L'invention porte sur des composés de la formule (I) dans laquelle R?3¿, R?4¿, R?7¿ et R?8¿ sont indépendamment sélectionnés dans le groupe comprenant hydrogène, alkyle inférieur, halogène, amine, mono-alkylamine(inférieur), phényle ou phényle substitué possédant une activité antitumorale et qui sont de nouveaux composés, à l'exception du composé dans lequel R?3¿, R?4¿, R?7¿, R?8¿ représentent tous hydrogène et du composé dans lequel R?3¿ et R?7¿ représentent hydrogène, R?4¿ chlore et R?8¿ est un groupe 2-nitrophényle.

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