Antitumour cellular compositions expressing at least three...

Details Antitumour cellular compositions expressing at least three... Antitumour cellular compositions expressing at least three...

C - Chemistry, Metallurgy

12

N

C12N 5/10 (2006.01) A61K 35/12 (2006.01) A61K 48/00 (2006.01) C07K 14/15 (2006.01) C07K 14/55 (2006.01) C07K 14/57 (2006.01) C12N 7/04 (2006.01) C12N 15/867 (2006.01)

Patent

CA 2250332

A novel antitumour composition including a cell population capable of expressing at least three therapeutic genes, particularly immunostimulatory and/or cytotoxic genes, is disclosed. A packaging cell expressing interleukin-2 and a retroviral vector expressing the gamma-interferon and thymidine kinase genes of herpes simplex virus 1 (HSV-1), as well as the therapeutical use thereof for preventing and treating cancer, are also disclosed.

La présente invention concerne une nouvelle composition antitumorale comprenant une population de cellules capables d'exprimer au moins trois gènes thérapeutiques et notamment des gènes immuno-stimulateurs et/ou cytotoxiques. Elle a également pour objet une cellule d'encapsidation exprimant l'interleukine-2 et un vecteur rétroviral exprimant les gènes interféron gamma et thymidine kinase du virus de l'herpès HSV-1 ainsi que leur utilisation thérapeutique pour la prévention et le traitement des cancers.

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