Antitumour synergistic composition

Details Antitumour synergistic composition Antitumour synergistic composition

A - Human Necessities

61

K

A61K 31/396 (2006.01) A61K 31/35 (2006.01) A61K 31/351 (2006.01) A61K 31/352 (2006.01) A61K 31/39 (2006.01) A61K 31/704 (2006.01) A61K 31/7048 (2006.01) A61K 31/7052 (2006.01) A61K 45/00 (2006.01) A61P 35/00 (2006.01) A61P 35/04 (2006.01)

Patent

CA 2361826

There are provided the combined use of 4-demethoxy-3'-deamino-3'-aziridinyl-4'- methansulfonyl daunorubicin or 4-demethoxy-N,N-bis(2-chloroethyl)-4'- methansulfonyl daunorubicin and an antineoplastic topoisomerase II inhibitor in the treatment of tumors and the use of said combination in the treatment or prevention of metastasis or in the treatment of tumors by inhibition of angiogenesis.

Cette invention concerne l'utilisation conjointe de 4-déméthoxy-3'-désamino-3'-aziridinyl-4'-méthanesulfonyle daunorubicine ou de 4-déméthoxy-N,N-bis(2-chloroéthyl)-4'-méthanesulfonyle daunorubicine et d'un inhibiteur de topoisomérase II antinéoplastique, pour le traitement des tumeurs, et l'utilisation de cette combinaison pour le traitement ou pour la prévention des métastases ou pour le traitement des tumeurs par inhibition de l'angiogénèse.

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