Antitussive and mucus regulating 2-substituted thiazolidines

Details Antitussive and mucus regulating 2-substituted thiazolidines Antitussive and mucus regulating 2-substituted thiazolidines

C - Chemistry, Metallurgy

07

D

167/208, 260/310

C07D 277/04 (2006.01) A61K 31/395 (2006.01) C07C 43/23 (2006.01) C07C 45/29 (2006.01) C07C 49/255 (2006.01) C07D 277/06 (2006.01) C07D 311/20 (2006.01) C07D 319/20 (2006.01) C07D 417/02 (2006.01) C07D 417/06 (2006.01) C07D 521/00 (2006.01)

Patent

CA 1270250

Abstract: ANTITUSSIVE AND MUCUS REGULATING 2-SUBSTITUTED THIAZOLIDI- NES 2-Substituted thiazolidines compounds having formu- la I Image (I) wherein X is a CH2, O or S, R is hydroxy or an acyl alkyloxy, alkenyloxy or alkinyloxy group, R1 is hydrogen or a group of formula Image R2 is hydrogen or a free or esterified carboxy group, Ra and Rb are hydrogen or methyl, p is zero or 1, R3 is hy- drogen, a C1-C2 alkylsulphonyl group, a phenyl or p-Cl phenyl, p-methylsulphonyl group or an acyl group; are useful as mucus regulating, antitussive and antibron- chospastic agents.

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