Antitussives

Details Antitussives Antitussives

A - Human Necessities

61

K

A61K 31/47 (2006.01) A61K 31/495 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2264928

Antitussives characterized by containing octahydroisoquinoline derivatives typified by compound (I) or pharmacologically acceptable acid-addition salts thereof. Because of having potent antitussive effects, these compounds are usable as drugs applicable to any disease associated with coughing, for example, various respiratory diseases such as, cold, acute bronchitis, chronic bronchitis, bronchiectasis, pneumonia, pulmonary tuberculosis, pulmonary silicosis, silicotuberculosis, pulmonary cancer, upper respiratory inflammation (pharyngeal catarrh, laryngeal catarrh and nasal catarrh), asthmatic bronchitis, bronchial asthma, infantile asthma, (chronic) pulmonary emphysema, pneumoconiosis, pulmonary fibrosis, pulmonary silicosis, pulmonary suppuration, pleurisy, tonsillitis, cough urticaria and whooping cough, and coughing associating bronchography, bronchoscopy, etc.

Ces antitussifs contiennent des dérivés octahydro-isoquinoline, caractérisés par le composé de la formule (I) ou par des sels d'addition d'acide de celui-ci, acceptables sur le plan pharmacologique. Grâce à leurs puissants effets antitussifs, on peut utiliser ces composés en tant que médicaments dans des maladies associées à la toux, par exemple, dans diverses maladies respiratoires comme le rhume, la bronchite aiguë, la bronchite chronique, la bronchectasie, la pneumonie, la tuberculose pulmonaire, la silicose pulmonaire, la silico-tuberculose, le cancer des poumons, l'inflammation des voies respiratoires supérieures (pharyngite catarrhale, laryngite catarrhale et rhino-pharyngite), la bronchite asthmatique, l'asthme bronchique, l'asthme infantile, l'emphysème pulmonaire (chronique), la pneumoconiose, la fibrose pulmonaire, la silicose pulmonaire, la suppuration pulmonaire, la pleurésie, l'amygdalite, la rougeole et la coqueluche, et la toux associée à une bronchographie, une bronchoscopie, etc.

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