Antitussives

Details Antitussives Antitussives

A - Human Necessities

61

K

A61K 31/381 (2006.01) A61P 11/14 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2520680

Antitussives containing as the active ingredient tricyclic compounds represented by the general formula (I) or pharmacologically acceptable salts thereof: (I) wherein R1 is hydrogen, substituted or unsubstituted lower alkyl, or the like; X1-X2-X3 is CR5=CR6-CR7=CR8 (wherein R5, R6, R7 and R8 are each independently hydrogen, substituted or unsubstituted lower alkyl, or the like) or the like; Y is -CH2S- or the like; and R2 is hydrogen, substituted or unsubstituted lower alkyl, or the like.

Antitussifs qui contiennent en tant que principe actif des composés tricycliques de formule générale (I) ou des sels pharmacologiquement acceptables desdits composés. Dans ladite formule, R?1¿ représente hydrogène, alkyle inférieur substitué ou non substitué, ou analogue, X?1¿-X?2¿-X?3¿ représentent CR?5¿=CR?6¿-CR?7¿=CR?8¿ (R?5¿, R?6¿, R?7¿ et R?8¿ représentant chacun indépendamment hydrogène, alkyle inférieur substitué ou non substitué, ou analogue) ou analogue, Y représente CH?2¿S- ou analogue et R?2¿ représente hydrogène, alkyle inférieur substitué ou non substitué, ou analogue.

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