Antiuracil monoclonal antibody

Details Antiuracil monoclonal antibody Antiuracil monoclonal antibody

C - Chemistry, Metallurgy

07

K

C07K 16/44 (2006.01) C07K 16/18 (2006.01) C12N 5/12 (2006.01) C12P 21/08 (2006.01) G01N 33/53 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2355893

A monoclonal antibody which reacts strongly with uracil and thymine but scarcely with N-carbamyl-.beta.-alanine; a hybridoma producing this monoclonal antibody; a method of immunochemically assaying uracil or thymine characterized by using the above-described monoclonal antibody; and diagnostics for dihydropyrimidine dehydrogenase (DPD) deficiency containing the above monoclonal antibody. Because of high sensitivity and specific reaction with uracil and thymine, the above-described monoclonal antibody enables convenient, quick, and selective assaying of uracil and thymine in a sample. The antibody is useful in screening patients with DPD deficient cancer with contraindication to the administration of pyrimidine fluoride- based antitumor agents.

L'invention concerne un anticorps monoclonal réagissant fortement à un uracil ou une thymine et réagissant à peine à N-carbamyl- beta -alanine; un hybridome produisant cet anticorps monoclonal; un procédé d'analyse immunochimique d'uracil ou thymine consistant à utiliser l'anticorps monoclonal précité; et des diagnostics de troubles liés à un manque de DPD contenant l'anticorps monoclonal précité. En raison de sa forte sensibilité et spécificité de réaction à l'uracil et à la thymine, l'anticorps monoclonal permet d'analyser de manière adéquate, rapide et sélective l'uracil et la thymine dans un échantillon. Cet anticorps convient au dépistage du cancer à déficience en DPD chez des patients pour lesquels l'administration d'agents antitumoraux à base de fluorure de pyrimidine est contre-indiquée.

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