C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/89 (2006.01) A61K 31/44 (2006.01) A61K 31/4425 (2006.01) A61K 31/47 (2006.01) A61L 2/16 (2006.01) A61P 39/00 (2006.01) C07D 215/60 (2006.01)
Patent
CA 2459774
As disclosed herein, the present invention provides a compound having the structural formula (I) wherein R1, R2, R3, and R4 are each independently H, or a methyl, halo, trifluoromethyl, nitro, alkyloxy, or acyloxy group, or a pharmaceutically acceptable salt or prodrug thereof. Also disclosed are compounds, compositions, methods and kits for treating, preventing, or inhibiting injuries induced by a vesicant agent, such as bis-2- chloroethylsulfide (HD). Additionally, protectants and decontaminants are disclosed.
L'invention concerne un composé de formule structurale (I) dans laquelle R?1¿, R?2¿, R?3¿, et R?4¿ représentent chacun, de manière indépendante, un atome d'hydrogène, ou un groupe méthyle, halo, trifluorométhyle, nitro, alkyloxy, ou acyloxy, ou une sel de ce composé, ou un promédicament de ce composé, acceptable sur le plan pharmaceutique. Elle concerne aussi des composés, des compositions, de procédés et des nécessaires destinés à traiter, prévenir, ou inhiber des blessures induites par un agent vésicant tel que le bis-2-chloroéthylsulfure (HD). Elle concerne encore des agents de protection et de décontamination.
Babin Michael C.
Lin Ai J.
Gowling Lafleur Henderson Llp
U.s. Army Medical Research And Materiel Command
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