Antiviral 1-aryl-5-amino-1-penten-3-ones

Details Antiviral 1-aryl-5-amino-1-penten-3-ones Antiviral 1-aryl-5-amino-1-penten-3-ones

C - Chemistry, Metallurgy

07

D

260/247.6

C07D 295/10 (2006.01) C07C 45/45 (2006.01) C07C 45/74 (2006.01) C07C 49/235 (2006.01) C07C 49/255 (2006.01) C07D 295/108 (2006.01) C07D 317/54 (2006.01) C07D 317/58 (2006.01)

Patent

CA 1175050

ABSTRACT OF THE DISCLOSURE Compounds of the formula Image wherein R is H, halo, C1-4 alkyl, C1-4 alkoxyl, 3,4-methylenedioxy, CF3, NO2, NH2, N(C1-4 alkyl2, CN, OH, -S(C1-4 alkyl) or -SO2(C1-4 alkykl); R1 and R2 are independently each H or C1-4 alkyl or taken together with the attacted N atom are morpholino, piperidino, pyrroidino, piperazino, or N- C1-4-alkyl piperazino; and, when R is halo, C1-4 alkyl or C1-4 alkoxy, x is 0-3 and, otherwise, is 0 or 1; or a pharmaceutically acceptable salt thereof with an acid or for the compounds wherein R1 and R2 are both not H, a quaternary ammonium salt thereof with a C1-4 alkyl halide have valuable antiviral activity, e.g., for treatment of infections caused by a herpes virus.

380891

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