Antiviral 5-(substituted benzal)hydantoins

Details Antiviral 5-(substituted benzal)hydantoins Antiviral 5-(substituted benzal)hydantoins

A - Human Necessities

61

K

167/237

A61K 31/415 (2006.01)

Patent

CA 1045550

ABSTRACT An antiviral, therapeutic composition presented by conventional pharmaceutical techniques in a form adapted to secure on its administration to mammals a dosage at the rate of 1 to 500 milligrams per kilogram of body weight per day, in single or multiple doses, of a substance of the following formula conveyed by a pharmaceutically acceptable carrier. Image I in which the hydantoin moiety is partially N-acetylated, and wherein: Formula I includes individual geometrical isomers and mixtures thereof, R1 is hydrogen or methoxy; R2 is hydrogen, methoxy or acetoxy; R3 is hydrogen, methoxy, or acetoxy; and R4 is hydrogen or methoxy; with the provisos that: R2 and R3 together may be - OCH2O provided that R1 and R4 are hydrogen; when R3 is acetoxy R1 and R4 are hydrogen and R2 is methoxy or acetoxy; and no more than two of R1, R2, R3 and R4 are methoxy.

287912

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