Antiviral activity and resolution of...

Details Antiviral activity and resolution of... Antiviral activity and resolution of...

C - Chemistry, Metallurgy

07

D

C07D 411/04 (2006.01) A61K 31/505 (2006.01) A61K 31/66 (2006.01) A61K 31/70 (2006.01) C07F 9/547 (2006.01) C07H 5/00 (2006.01) C07H 19/06 (2006.01) C12P 41/00 (2006.01)

Patent

CA 2104399

A method and composition for the treatment of HIV and HBV infections in humans is disclosed that includes administering an effective amount of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1.3- oxathiolane, a pharmaceutically acceptable derivative thereof, including a 5' or N4 alkylated or acylated derivative, or a pharmaceutically acceptable salt thereof, in a pharmaceutically acceptable carrier. A process for the resolution of a racemic mixture of nucleoside enantiomers is also disclosed that includes the step of exposing the racemic mixture to an enzyme that preferentially catalyzes a reaction in one of the enantiomers.

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