C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/242.4
C07D 473/18 (2006.01) C07D 473/00 (2006.01) C07F 9/6561 (2006.01)
Patent
CA 1225400
ANTIVIRAL AGENTS ABSTRACT OF THE DISCLOSURE (S)-9-(2,3-dihydroxy-1-propoxymethyl)- guanine has potent antiherpetic activity which is superior to the corresponding racemic mixture or the (R)-enantiomer and also is much more potent than 9-(2-hydroxyethoxymethyl)guanine. Acyl derivatives (prodrugs) of the (S)-enantiomer, which are more effective than the corresponding (R)-enantiomer analogs or related racemic mixtures provide formulation advantages and even higher plasma half lives in animals or man than the (S)-isomer.
457140
Ashton Wallace T.
Canning Laura F.
Field Arthur K.
Tolman Richard L.
Goudreau Gage Dubuc
Merck & Co. Inc.
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