Antiviral agents

Details Antiviral agents Antiviral agents

C - Chemistry, Metallurgy

07

D

260/242.4

C07D 473/18 (2006.01) C07D 473/00 (2006.01) C07F 9/6561 (2006.01)

Patent

CA 1225400

ANTIVIRAL AGENTS ABSTRACT OF THE DISCLOSURE (S)-9-(2,3-dihydroxy-1-propoxymethyl)- guanine has potent antiherpetic activity which is superior to the corresponding racemic mixture or the (R)-enantiomer and also is much more potent than 9-(2-hydroxyethoxymethyl)guanine. Acyl derivatives (prodrugs) of the (S)-enantiomer, which are more effective than the corresponding (R)-enantiomer analogs or related racemic mixtures provide formulation advantages and even higher plasma half lives in animals or man than the (S)-isomer.

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