C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
167/202, 167/218
C07H 19/04 (2006.01) A61K 31/70 (2006.01) C07F 9/65 (1985.01)
Patent
CA 1257256
NOVEL ANTIVIRAL AGENTS Abstract Phosphonate analogues of mono-, di-, and tri- phosphates of antiviral nucleoside analogues are dis- closed. These materials are represented structurally as Image wherein Z1 and Z2 are the same or different and selected from the group made up of hydrogen, the one to six car- bon alkyls, phenyl and benzyl, X is H, OH, or together with Y = O, Y is H or together with X = O, n is an integer, O, 2 or 4, R1 and R2 together complete a .beta.-pentofuranose sugar or R1 is H and R2 is H or -CH2OH, R3 is H or OH and B is a purine or pyrimidine base. These materials have antiviral activity, expecially against herpes virus. Antiviral pharmaceutical prepara- tions and their use are disclosed as well.
458084
Reist Elmer J.
Sturm Priscilla A.
Gowling Lafleur Henderson Llp
Sri International
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