Antiviral agents

Details Antiviral agents Antiviral agents

C - Chemistry, Metallurgy

07

H

167/202, 260/229

C07H 19/04 (2006.01) A61K 31/70 (2006.01) C07H 19/06 (2006.01) C07H 19/10 (2006.01) C07H 19/16 (2006.01) C07H 19/20 (2006.01)

Patent

CA 2003408

26530-FF ABSTRACT OF THE DISCLOSURE Nucleoside compounds of the formula Image wherein: B is guanine, adenine, thymine, uracil, cytosine, hypoxanthine, xanthine, 5-methylcytosine, 4-ethoxy- 5-methyl-2-oxo-pyrimidine, 4-isopropoxy-5-methyl-2-oxo- pyrimidine, or 5-methyl-2-oxo-pyrimidine; X is H or F; Y' is H, OH, OCH3 or F; and Z is Image or Image where n is zero, one, or three and both R' are hydrogen or lower alkyl; or Y' and Z together form a cyclic phosphate ester, and the pharmaceutically acceptable esters, ethers and salts thereof, have been found to have potent antiviral activity with a high therapeutic ratio.

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