Antiviral agents

Details Antiviral agents Antiviral agents

C - Chemistry, Metallurgy

07

H

C07H 19/04 (2006.01) A61K 9/127 (2006.01) A61K 31/70 (2006.01) C07H 19/10 (2006.01) C07H 19/20 (2006.01)

Patent

CA 2042795

26530/2-FF ABSTRACT OF THE DISCLOSURE Nucleoside compounds of the formula Formula I Image wherein: B is a purine or a pyrimidine; X and X' are H, OH or F, provided that at least one is H; Y and Y' are H, OH, OCH3 or F, provided that at least one is H; Y' and Z together form a cyclic phosphate ester, provided that Y is H; or Z is Image where n is zero, one, two or three; and Z' is N3 or OCH3; provided that when X' and Y' are OH and Z' is N3, B is not cytosine, when X' and Y' are OH and Z' is OCH3, B is not uracil, adenine or cytosine, and when Z' is N3, X' is H, and Y' is H, OH, OCH3, or F, B is not purine, cytosine, uracil, or thymine; 26530/2 26530/2-FF and the pharmaceutically acceptable esters; ethers and salts thereof, have been found to have potent antiviral activity with a high therapeutic ratio. 26530/2 26530/2-FF

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