A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/505 (2006.01) A61K 31/52 (2006.01) A61K 31/70 (2006.01)
Patent
CA 2344172
The present invention relates to therapeutic combinations comprising (2R, cis) -4-amino-1- (2-hydroxymethyl-1, 3-oxathiolan-5-yl) -pyrimidin-2-one (lamivudine) and a second therapeutic agent selected from (9-[(R) -2- (phosphonomethoxy) ethyl]adenine, (PMEA or adefovir) and bis(pivaloyloxymethyl) (9-[(R) -2- (phosphonomethoxy)ethyl]adenine, (the oral prodrug of PMEA, adefovir dipivoxil) w hich have anti-hepatitis B virus (HBV) activity. The present invention is also concerned with pharmaceutical compositions containing said combinations and their use in the treatment of HBV infections including infections with HBV mutants bearing resistance to nucleoside and/or non-nucleoside inhibitors.
L'invention concerne des combinaisons thérapeutiques comprenant une (2R,cis)-4-amino-1-(2-hydroxyméthyl-1,3-oxathiolan-5-yl)-pyrimidin-2-one (lamivudine) ainsi qu'un second agent thérapeutique choisi dans le groupe constitué par (9-[(R)-2-(phosphonométhoxy)éthyl]adénine, (PMEA ou adéfovir) et bis(pivaloyloxyméthyl)(9-[(R)-2-(phosphonométhoxy)éthyl]adénine, (promédicament oral de PMEA ou adéfovir dipivoxil), lesquels possèdent une activité dirigée contre le virus de l'hépatite B (HBV). L'invention concerne également des compositions pharmaceutiques contenant ces combinaisons ainsi que l'utilisation de ces compositions dans le traitement d'infections à HBV, notamment d'infections provoquées par des mutants de ce virus, lesquels sont résistants aux inhibiteurs nucléosidiques et/ou non nucléosidiques.
Brown Nathaniel A.
Condreay Lynn D.
Gray Douglas Fraser
Rubin Marc
Glaxo Group Limited
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
LandOfFree
Antiviral combinations does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Antiviral combinations, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antiviral combinations will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-2001874