C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/220, 260/242
C07D 473/00 (2006.01) A61K 31/52 (2006.01) C07F 9/547 (2006.01)
Patent
CA 1308714
ABSTRACT Compounds of the general formula (I) Image (I) wherein X is sulphur or oxygen or a chemical bond; R1 is halogen, amino or azido; R2 is hydrogen, hydroxy, C1-8 alkyl or hydroxy -C1-8- alkyl; R3 is hydrogen or C1-8alkyl; R is hydroxy, hydroxy -C1-8- alkyl, benzyloxy, phosphate or carboxypropionyloxy; R5 is hydrogen, C1-8 alkyl or hydroxy -C1-8 alkyl; and physiologically acceptable esters of those compounds wherein R2 is hydroxy or hy- droxy -C1-8- alkyl, R4 is hydroxy, hydroxy -C1-8- alkyl or carboxy- propionyloxy or R5 is hydroxy -C1-8- alkyl; and physiologically acceptable salts of such compounds of formula (I) and their esters; the compounds whereln X is oxygen, R1 is amino, R2, R3 and R5 are each hydrogen and R4 is hydroxy, are provided; these com- pounds have valuable antiviral activity particularly against herpes virus.
512737
Beauchamp Lilia Maria
Krenitsky Thomas Anthony
Schaeffer Howard John
Beauchamp Lilia Maria
Krenitsky Thomas Anthony
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Schaeffer Howard John
The Wellcome Foundation Limited
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