Antiviral indoleoxoacetyl piperazine derivatives

A - Human Necessities – 61 – K

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Details

A61K 31/496 (2006.01) C07D 209/12 (2006.01) C07D 209/18 (2006.01) C07D 401/12 (2006.01) C07D 403/06 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/04 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 495/12 (2006.01) H04Q 7/38 (2006.01)

Patent

CA 2340663

This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with indoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.

L'invention concerne des composés possédant des propriétés de médicament et d'action biologique, des compositions pharmaceutiques contenant ces composés ainsi que des procédés d'utilisation associés. L'invention concerne notamment des dérivés d'indoleoxoacétylpipérazine. Ces composés possèdent une activité antivirale unique, qu'ils soient utilisés seuls ou en combinaison avec d'autres antiviraux, ou avec des anti-infectieux, des immunomodulateurs ou des inhibiteurs de l'entrée du VIH. L'invention concerne tout particulièrement le traitement du VIH et du SIDA.

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