Antiviral oligonucleotides

Details Antiviral oligonucleotides Antiviral oligonucleotides

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) A61K 31/7125 (2006.01) A61K 31/713 (2006.01) A61K 48/00 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2584207

Random sequence oligonucleotides that have antiviral activity are described, along with their use as antiviral agents. In many cases, the oligonucleotides are greater than 40 nucleotides in length and include chemical modifications, such as modified internucleotidic linkages and modifications at the 2'- position of the ribose moieties. Also described are uses for the prophylaxis or treatment of a viral infection in a human or animal, and use for the prophylaxis or treatment of cancer caused by oncoviruses in a human or animal. The uses typically involve administering to a human or animal in need of such treatment, a pharmacologically acceptable, therapeutically effective amount of at least one oligonucleotide that act by a sequence independent mode of action.

L'invention concerne des oligonucléotides de séquence aléatoire possédant une activité antivirale, ainsi que leur utilisation comme agents antiviraux. Dans de nombreux cas, les oligonucléotides comprennent plus de 40 nucléotides en longueur et présentent des modifications chimiques, telles que des liaisons internucléotidiques modifiées et des modifications au niveau de la position 2' des groupes ribose. L'invention concerne également des utilisations en prévention ou traitement d'une infection virale chez l'homme ou l'animal, ainsi qu'une utilisation en prévention ou traitement d'un cancer dû à des oncovirus chez l'homme ou l'animal. Ces utilisations consistent généralement à administrer à un être humain ou un animal nécessitant un tel traitement une dose thérapeutique efficace pharmacologiquement acceptable d'au moins un oligonucléotide agissant selon un mode d'action indépendant de la séquence.

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