Antiviral peptides

Details Antiviral peptides Antiviral peptides

C - Chemistry, Metallurgy

07

K

C07K 5/03 (2006.01) A61K 31/395 (2006.01) A61K 38/05 (2006.01) C07D 205/04 (2006.01) C07D 205/08 (2006.01) C07D 207/14 (2006.01) C07D 207/404 (2006.01) C07D 211/26 (2006.01) C07D 211/58 (2006.01) C07D 211/74 (2006.01) C07D 307/33 (2006.01) C07D 401/02 (2006.01) C07D 401/12 (2006.01) C07D 403/02 (2006.01) C07D 405/10 (2006.01) C07D 405/12 (2006.01) C07D 407/10 (2006.01) C07D 409/12 (2006.01) C07D 413/02 (2006.01) C07F 7/18 (2006.01)

Patent

CA 2133583

2133583 9323373 PCTABScor01 Compounds of formula (I) wherein R1 is C1-C6 alkyl, C3-C8 cycloalkyl, aryl, heterocyclyl, or R7R8NCO; R2 is C1-C6 alkyl, C3-C8 cycloalkyl(C1-C4)alkyl, aryl(C1-C4)alkyl, or heterocyclyl(C1-C4)alkyl; R3 is C1-C6 alkyl, C3-C8 cycloalkyl, C3-C8 cycloalkyl(C1-C4)alkyl, aryl(C1-C4)alkyl, aryl(C2-C4)alkenyl, heterocyclyl(C1-C4)alkyl or heterocyclyl(C2-C4)alkenyl; R4 is C1-C6 alkyl, C3-C8 cycloalkyl, aryl or heterocyclyl; R5 and R6 are each independently H, C1-C6 alkyl, C3-C7 cycloalkyl, or C1-C6 alkyl substituted by C1-C4 alkoxy, hydroxy or NR7R8; or R5 and R6 are linked to form, together with the nitrogen atom to which they are attached, a pyrrolidine, piperidine, morpholine, piperazine or N-(C1-C4 alkyl) piperazine group; each of R7 and R8 is independently H, C1-C6 alkyl or C3-C8 cycloalkyl or R7 and R8 may be joined together to form, with the nitrogen to which they are attached, a 4 to 8 membered nitrogen-containing heterocyclic group; each of R9, R10, R11 and R12 is independently H, C1-C6 alkyl or C3-C8 cycloalkyl; or R9 and R10, or R11 and R12 may be joined together to form a 3 to 8 membered carbocyclic ring; X is a 4-10 membered mono- or bicyclic heterocyclic group containing carbon ring atoms and one ring nitrogen atom through which the group is attached to the adjacent carbonyl group; the group may be saturated or partially unsaturated and, in addition to the -(CR11R12)m -NR5R6 substituent, it may be substituted by up to 4 further substituents each independently chosen from F, C1-C6 alkyl, C3-C8 cycloalkyl, OH, C1-C6 alkoxy or NR7R8; and n and m are each independently 0, 1 or 2; and wherein any alkyl or cycloalkyl group included in the aforementioned definitions may optionally be fully or partially substituted by fluorine; are inhibitors of retroviral proteases of utility in the treatment and prophylaxis of human retroviral infections.

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