Antiviral peptides having a 2-oxoalkyl amino acid side chain

Details Antiviral peptides having a 2-oxoalkyl amino acid side chain Antiviral peptides having a 2-oxoalkyl amino acid side chain

C - Chemistry, Metallurgy

07

K

167/300, 530/7.0

C07K 7/06 (2006.01) A61K 38/06 (2006.01) A61K 38/07 (2006.01) A61K 38/08 (2006.01) C07K 5/103 (2006.01) C07K 14/035 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1340682

Disclosed herein are peptide derivatives of the formula X[-NR1-CH(R2)-C(W1)]n-NH-CR3(R4)-C(W2)-NR5-CH[CH2- C(O)-Y]-C(W3)-NH-CR6-[CR7(R8)-COOH]-C(W4)-NH-CR9(R10)-Z wherein X is a terminal group, for example, alkanoyl or phenyl-alkanoyl radicals, R1 is hydrogen, alkyl or phenylalkyl, R2, R4 and R10 are selected from amino acid or derived amino acid residues, R3, R5, R6, R7, R8 and R9 are hydrogen or lower alkyl, W1, W2, W3 and W4 are oxo or thioxo, Y is, for example, an alkyl or a cyclo-alkyl, Z is a terminal group, for example, COOH or CH2OH, and n is 0 or 1. The derivatives are useful for treating herpes infections.

605062

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