Antiviral phosphoramidates of 4 ' -substituted pronucleotides

C - Chemistry – Metallurgy – 07 – H

Patent

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Details

C07H 19/20 (2006.01) A61K 31/7064 (2006.01) A61K 31/7076 (2006.01) C07H 19/10 (2006.01)

Patent

CA 2618335

The invention provides novel nucleoside compounds of formula I wherein R1, R2a, R2b, R3, R4, R5, R6, R8a, R9 and R10 are as defined herein which are useful for the treatment of Hepatitis C Virus (HCV) mediated diseases. The invention further provides methods for treatment or prophylaxis of HCV mediated diseases with compounds of formula I and pharmaceutical compositions comprising these compounds.

L'invention concerne des nouveaux composés nucléosides de formule (I) dans laquelle R1, R2a, R2b, R3, R4, R5, R6, R8a, R9 et R10 ont la signification indiquée dans la description, qui sont utilisés pour le traitement de maladies à médiation assurée par le virus de l'hépatite C (VHC). L'invention concerne en outre des méthodes de traitement ou de prophylaxie de maladies à médiation assurée par le VHC à l'aide des composés de formule (I) et des compositions pharmaceutiques comprenant lesdits composés.

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