Antiviral prodrugs

Details Antiviral prodrugs Antiviral prodrugs

A - Human Necessities

61

K

A61K 31/70 (2006.01) C07H 19/052 (2006.01) C07H 19/056 (2006.01)

Patent

CA 2400043

Prodrug forms of Levovirin include bio-reversible modifications on the sugar moiety and/or bio-reversible modifications on the triazole moiety. Contemplated prodrug forms may be used in pharmaceutical compositions, which may be used to treat an infection, an infestation, a neoplasm, or an autoimmune disease. Further contemplated uses include immunomodulation, and particularly modulation of Type 1 and Type 2 cytokine expression.

La présente invention concerne des formes de promédicaments à base de Levovirin qui présentent des modifications bio-réversibles sur la fraction sucre et/ou des modifications bio-réversibles sur la fraction triazole. On peut utiliser les formes de promédicaments visées dans des compositions pharmaceutiques pouvant être utilisées pour traiter une infection, une infestation, un néoplasme, ou une maladie auto-immune. Ces formes de promédicaments peuvent avoir d'autres utilisations, notamment dans l'immunomodulation, et particulièrement la modulation de l'expression des cytokines de type 1 et de type 2.

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