Antiviral protease inhibitors

Details Antiviral protease inhibitors Antiviral protease inhibitors

C - Chemistry, Metallurgy

07

C

C07C 237/04 (2006.01) A61K 31/165 (2006.01) A61P 31/18 (2006.01) C07C 235/36 (2006.01) C07C 237/06 (2006.01) C07C 237/22 (2006.01) C07D 221/16 (2006.01)

Patent

CA 2458040

Compounds of the formula (I) wherein: X and Y are hydroxy or H. A' and A'' are terminal amine functions such valinamide or indanolamine. Z' and Z'' along with the adjacent ()n groups are independently alkylaryl have utility as HIV aspartyl protease inhibitors with particularly good activity in the presence of human serum.

L'invention concerne des composés de la formule (I) où X et Y représentent hydroxy ou H. A' et A'' sont des fonctions amine terminale telles que valinamide ou indanolamine. Z', Z'' et les ( )n groupes adjacents représentent indépendamment alkylaryle. Ces composés sont utiles comme inhibiteurs d'aspartyle sida-protéase ayant une activité particulièrement bonne en présence de sérum humain.

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