Antiviral pyrimidine nucleosides

C - Chemistry – Metallurgy – 07 – H

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C07H 19/06 (2006.01) A61K 31/70 (2006.01) C07H 15/18 (2006.01)

Patent

CA 2143834

Antiviral nucleosides of formula (I), wherein: Y is hydroxy or amino; X is hydrogen, hydroxy, mercapto, halo, trifluorome- thyl, methyl, C2-6alkyl, C1-6haloalkyl, hydroxyC1-3alkyl, formyl, C2-6alkenyl, C2-6haloalkenyl, C2-6alkynyl, C1-6alkoxy, C1-6alkylthio, C1-6alkoxyC1-2alkyl, C1-6alkylthiomethyl, amino, monoC1-6alkylamino, diC1-6alkylamino, cyano, thiocyanate or nitro; R2 is hydrogen and R3 is hydroxy or hydrogen, or together R2 and R3 form a carbon-carbon bond; and physiologi- cally functional derivations thereof. Compositions containing the compounds, their use in treatment and therapy of viral dis- ease, and processes for the production of the compounds are also provided.

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