C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 19/06 (2006.01) A61K 31/70 (2006.01) C07H 15/18 (2006.01)
Patent
CA 2143834
Antiviral nucleosides of formula (I), wherein: Y is hydroxy or amino; X is hydrogen, hydroxy, mercapto, halo, trifluorome- thyl, methyl, C2-6alkyl, C1-6haloalkyl, hydroxyC1-3alkyl, formyl, C2-6alkenyl, C2-6haloalkenyl, C2-6alkynyl, C1-6alkoxy, C1-6alkylthio, C1-6alkoxyC1-2alkyl, C1-6alkylthiomethyl, amino, monoC1-6alkylamino, diC1-6alkylamino, cyano, thiocyanate or nitro; R2 is hydrogen and R3 is hydroxy or hydrogen, or together R2 and R3 form a carbon-carbon bond; and physiologi- cally functional derivations thereof. Compositions containing the compounds, their use in treatment and therapy of viral dis- ease, and processes for the production of the compounds are also provided.
Miller John A.
Rahim Saad G.
Selwood David L.
Walker Richard
Young Robert J.
Swabey Ogilvy Renault
The Wellcome Foundation Limited
University Of Birmingham
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