Antiviral tetrahydroimidazo [1,4]benzodiazepin-2-(thi)ones

Details Antiviral tetrahydroimidazo [1,4]benzodiazepin-2-(thi)ones Antiviral tetrahydroimidazo [1,4]benzodiazepin-2-(thi)ones

C - Chemistry, Metallurgy

07

D

C07D 487/06 (2006.01) A61K 31/55 (2006.01)

Patent

CA 2086547

2086547 9200979 PCTABS00010 Novel tetrahydroimidazo[1,4]benzodiazepin-2-(thio)ones of formula (I), the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein X is O or S; R1 is a radical of formula (a-1); (a-2); (a-3) or (a-4); R2 is hydrogen or C1-6alkyl; R3 is hydrogen or C1-6alkyl; R4 and R5 each independently are hydrogen, C1-6alkyl, halo, cyano, nitro, trifluoromethyl, hydroxy, C1-6alkyloxy, amino, mono- or di(C1-6alkyl)amino, C1-6alkylcarbonylamino or arylcarbonylamino, possessing antiviral activity. Compositions containing these compounds as active ingredient and methods of treating subjects suffering from viral infections by administering said compounds.

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