Antiviral tetrahydroimidazol [1,4] benzodiazepines

Details Antiviral tetrahydroimidazol [1,4] benzodiazepines Antiviral tetrahydroimidazol [1,4] benzodiazepines

C - Chemistry, Metallurgy

07

D

C07D 487/06 (2006.01) C07D 243/14 (2006.01)

Patent

CA 2064782

2064782 9104255 PCTABS00003 Tetrahydroimidazo[1,4]benzodiazepines of formula (I), wherein R1 is C1-6alkyl optionally substituted with aryl; C3-6alkynyl; C3-6cycloalkyl; or a radical of formula (a); (b); (c) or -Alk-S(O)m-R15; R2, R3 and R7 are hydrogen or C1-6alkyl; R4 and R5 are hydrogen, C1-6alkyl, halo, cyano, nitro, trifluoromethyl, hydroxy, C1-6alkyloxy, amino, mono- or di(C1-6alkyl)amino, (C1-6alkyl or aryl)carbonylamino; R6 is C1-6alkyl; and X is OH, SH or NR16R17; the acid addition salts and stereochemically isomeric forms thereof; said compounds having antiretroviral activity. Pharmaceutical compositions comprising said compounds as active ingredient and methods of preparing said compounds and pharmaceutical compositions.

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