Antiviral therapy

Details Antiviral therapy Antiviral therapy

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/713 (2006.01) A61P 31/18 (2006.01) C07K 14/16 (2006.01) C12N 15/49 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2409772

A polynucleotide which is (i) an antisense polynucleotide that binds the splice-donor/packaging signal region (SD/.psi.) or the TAR region of HIV-1 RNA, or (ii) a vector polynucleotide capable of expressing (i); for use in a method of treating or preventing HIV infection.

Cette invention a trait à un polynucléotide qui, (i) est un polynucléotide antisens se fixant à la région donneur d'épissure/signal d'encapsidation (SD .psi.) de la région TAR de l'ARN du VIH-1 ou, (ii) un polynucléotide capable d'exprimer le polynucléotide (i). Le polynucléotide selon l'invention est utilisé dans le cadre d'une thérapie ou d'une prophylaxie de l'infection par VIH.

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