Antiviral therapy using thiazine and xanthene dyes

Details Antiviral therapy using thiazine and xanthene dyes Antiviral therapy using thiazine and xanthene dyes

A - Human Necessities

61

K

A61K 31/54 (2006.01) A61K 31/35 (2006.01) C12N 7/04 (2006.01) A61M 1/36 (2006.01)

Patent

CA 2055463

A method for using thiazine and xanthene dyes to selectively inactivate or inhibit intracellular replication of specific viruses, especially human immunodeficiency virus. Examples of useful xanthine dyes are rose bengal and eosin Y. A preferred thiazine dye is methylene blue. The dyes interfere with transcription and translation of viral nucleic acid. Light penetrating the skin to the capillaries at the surface can be used to enhance the activity of the dye.

Méthode d'utilisation des colorants de thiazine et de xanthène pour inactiver ou inhiber de façon sélective la reproduction intracellulaire de certains virus, particulièrement les virus de l'immunodéficience humaine. Le rose Bengale et l'éosine Y sont des exemples de colorants efficaces de xanthène. Le bleu de méthylène est un colorant de thiazine de choix. Les colorants entravent la transcription et la traduction de l'acide nucléique viral. La lumière qui pénètre la peau vers les capillaires à la surface peut servir à augmenter l'activité du colorant.

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