Antizyme modulators and their use

Details Antizyme modulators and their use Antizyme modulators and their use

C - Chemistry, Metallurgy

07

C

C07C 211/01 (2006.01) A61K 31/132 (2006.01) C07C 211/14 (2006.01) C07C 211/15 (2006.01) C07C 211/27 (2006.01) C07C 211/53 (2006.01) C07C 211/54 (2006.01) C07C 215/58 (2006.01) C07C 233/36 (2006.01) C07C 233/37 (2006.01) C07C 237/10 (2006.01) C07C 251/38 (2006.01) C07C 279/12 (2006.01) C07C 279/26 (2006.01) C07D 211/26 (2006.01) C07D 213/36 (2006.01) C07D 219/04 (2006.01) C07D 233/16 (2006.01) C07D 233/52 (2006.01) C07D 295/13 (2006.01) C07D 307/91 (2006.01) C07D 333/34 (2006.01) C07D 417/04 (2006.01)

Patent

CA 2362259

The present invention is directed to agmatine and polyamine analogs and their use as drugs, as well as agricultural or environmentally useful agents. As drugs, the analogs decrease cellular polyamine levels, possibly by inducing antizyme, and can be used to treat disorders of undesired cell proliferation, including cancer, viral infections and bacterial infections. The analogs may be utilized in pharmaceutical compositions either alone or in combination with other agents, particularly other inhibitors of polyamine synthesis or transport, but including other inhibitors of cell proliferation. The analogs are not necessarily metabolized to contribute to the polyamine pool and are designed to enter cells by pathways independent of polyamine transport. The invention further defines structural elements/motifs within these analogs that are key to their induction of antizyme.

L'invention concerne des analogues d'agmatine et de polyamine et leur utilisation comme médicaments et comme agents utiles en liaison avec l'agriculture ou l'environnement. En tant que médicaments, les analogues font baisser les niveaux de polyamine cellulaire, éventuellement par induction d'antizymes, et on peut les utiliser pour le traitement de la prolifération cellulaire non désirée, y compris le cancer, les infections virales et les infections bactériennes. On peut utiliser ces analogues dans des compositions pharmaceutiques, seuls ou en combinaison avec d'autres agents, en particulier d'autres inhibiteurs de la synthèse ou du transport de polyamine, mais avec incorporation d'autres inhibiteurs de la prolifération cellulaire. Les analogues ne sont pas nécessairement métabolisés pour contribuer au pool de polyamine, et ils sont conçus pour pénétrer dans les cellules par des trajets indépendants des trajets de transport de la polyamine. L'invention concerne en outre la définition d'éléments/motifs structurels qui, dans ces analogues, sont déterminants pour l'induction d'antizymes.

Affiliated with

Also associated with

Rating

Antizyme modulators and their use does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antizyme modulators and their use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antizyme modulators and their use will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1856194